BDBM10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1
SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
InChI Key InChIKey=BZKPWHYZMXOIDC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 586 hits for monomerid = 10880
Affinity DataKi: 0.0120nMAssay Description:Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 dehydration methodMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.343nMAssay Description:Binding affinity to human CA2 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.343nM ΔG°: -12.9kcal/mole IC50: 0.485nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Affinity DataKi: 0.940nMAssay Description:Inhibition of human CAH2 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.90nMAssay Description:Inhibition assay using carbonic anhydrases.More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibitory activity against human carbonic anhydrase IIMore data for this Ligand-Target Pair
Affinity DataKi: 7.90nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by dansylamide (DNSA) competition assayMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Binding affinity to human recombinant CA2 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2...More data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow carbon dioxide hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of human CA2 by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of human recombinant CA2 by CO2 hydration stopped flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 10.1nMAssay Description:Inhibition assay using carbonic anhydrases.More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of carbonic anhydrase-2 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue i...More data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.6kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.6kcal/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.8kcal/molepH: 7.4 T: 2°CAssay Description:Inhibition assay using human Carbonic anhydrase I and II and bovine carbonic anhydrase IV. More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition assay using carbonic anhydrases.More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:CA-catalyzed CO2 hydration activity methods were published previously by Cornelio et al. as part of a larger series of benzenesulfonamide-based inhib...More data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.8kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.0kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.8kcal/molepH: 7.4 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.6kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Helicobacter pylori alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of recombinant human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human recombinant cytosolic human carbonic anhydrase-2 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.8kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydrase...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 6 hrs by stopped flow carbon-di-oxide hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human carbonic anhydrase-2 assessed as CO2 hydration activity by stopped-flow methodMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli preincubated for 6 hrs by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human recombinant CA2 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human carbonic anhydrase 2 measured by CO2 hydration reaction assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human carbonic anhydrase 2 by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human carbonic anhydrase 2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human cloned cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human CA-2 after 15 mins by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair